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Welcome to the Kisley Lab

Materials at the ultimate concentration limit

We are a team of physicists, chemists, and engineers driven by curiosity to understand the world at the limit of a single molecule.

We study materials using nanoscale microscopy. We have the goal to inspire materials design through the following aims:


1) Approach medical & industrial material problems with a molecular, quantitative perspective using single molecule spectroscopy. Single molecule spectroscopy accesses heterogeneity hidden in traditional ensemble measurements.

2) Advance the single molecule materials field towards more complex, realistic conditions. We have a long-term vision of connecting the molecular results to the macroscale material performance.

3) Develop new microscopies that achieve a full physicochemical picture of molecular behavior. This includes how molecules adsorb, diffuse, and fold over space, time, and temperature.


Please check out our website for more details!


1) Research Associate in Soft matter, biophysics, and expansion microscopy

2) Postdoctoral Researcher in Microscopy

3) Undergraduate think[box] engineer

Image by National Cancer Institute

Research & Discoveries

The Kisley Lab images molecules interacting with bio/soft/metal materials using microscopy.
We track how molecules stick, move, react, or change conformation over space, time, and temperature.

Image by Josie Weiss

Protein Dynamics in the Extracellular Matrix

How do proteins behave outside the cell?


Diffusion and Adsorption of Analytes in Separation Materials

Designing the most challenging separations from the bottom-up

Image by Tengyart

Imaging Corrosion, One Redox Reaction at a Time

Detecting & understanding rust right when it starts


New High-Resolution Microscopy Methods

Reaching new scales even with noisy or low signal data

Learn more about our research:

Notable News

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Lydia gives keynote presentation at CWRU's first Biophysics Week event


The CWRU Postdoc Association’s Professional Development Committee hosted the inaugural CWRU Biophysics Day! The purpose of the event was to celebrate biophysics, promote interdisciplinary collaboration, share research being done on campus. Lydia was invited to give the featured Research Talk and covered the lab's work on imaging the extracellular environment.

Congratulations - JES publication


Congratulations to Lian, Zechariah, and Mark on their article "A turn-off fluorescent sensor for metal ions quantifies corrosion in an organic solvent" in the Journal of the Electrochemical Society.  Check it out here:

Group attends APS March Meeting

3/3- 3/8/2024

The Kisley Lab took over the APS March Meeting in Minneapolis! The group had seven talks & one poster over the course of the meeting in DBIO, DSOFT, DCP, DPOLY, DFD, and GIMS.

Contact Us

Rockefeller Bldg.
2076 Adelbert Rd.
Cleveland, OH 44106-7079


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