We are hiring!

We are hiring two postdoctoral researchers:

  1. Biophysics and expansion microscopy, starting January 2023 at the earliest. Apply here: https://apply.interfolio.com/116336

  2. Corrosion and single-molecule microscopy, starting ASAP. Apply here: https://apply.interfolio.com/116335

More details regarding the specifics of the positions are included through the Interfolio links. Please contact Lydia if you have any questions.


Welcome to the Kisley Lab

Microscopy & Materials

We are a team of physicists, chemists, and engineers driven by curiosity to understand the world at the ultimate concentration limit of a single molecule.

We study materials using nanoscale microscopy. We have the goal to inspire materials design through the following aims:

1) Approach medical & industrial material problems with a molecular, quantitative perspective using single molecule spectroscopy. Single molecule spectroscopy accesses heterogeneity hidden in traditional ensemble measurements.

2) Advance the single molecule materials field towards more complex, realistic conditions. We have a long-term vision of connecting the molecular results to the macroscale material performance.

3) Develop new microscopies that achieve a full physicochemical picture of molecular behavior. This includes how molecules adsorb, diffuse, and fold over space, time, and temperature.

Please check out our website for more details!

Image by National Cancer Institute

Research & Discoveries

The Kisley Lab images molecules interacting with bio/soft/metal materials using microscopy.
We track how molecules stick, move, react, or change conformation over space, time, and temperature.

Image by Josie Weiss

Protein Dynamics in the Extracellular Matrix

How do proteins behave outside the cell?


Diffusion and Adsorption of Analytes in Separation Materials

Designing the most challenging separations from the bottom-up

Image by Tengyart

Imaging Corrosion, One Redox Reaction at a Time

Detecting & understanding rust right when it starts


New High-Resolution Microscopy Methods

Reaching new scales even with noisy or low signal data

Learn more about our research:


Notable News

surajit poster.png

Lydia recognized by 3M's Non-Tenured Faculty Award (NTFA)


The NTFA from 3M recognizes excellent junior faculty members who have been nominated by 3M researchers for their demonstrated record of research, experience, and academic leadership. The award will help support our lab’s research activities in imaging porous materials. Lydia will present her research to 3M's corporate headquarters later this year along with the other national awardees.

Surajit's 1st place poster


Congrats to Dr. Surajit Chatterjee on being awarded 1st place in the poster session at the Cleveland Center for Membrane & Structural Biology Symposium! Surajit shared his past research on DNA dynamics w/ Prof. Nils Walter's lab & his current work imaging biomolecule dynamics in the ECM. Way to represent the lab & also show that nanoscale dynamics are just as informative as static, Angstrom-level images :)

Congratulations - Zack passes his Masters thesis defense!


Zack presented and defended his work on studying corrosion with fluorescence in non-aqueous environments.


Contact Us

Rockefeller Bldg.
2076 Adelbert Rd.
Cleveland, OH 44106-7079