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Welcome to the Kisley Lab

Materials at the ultimate concentration limit

We are a team of physicists, chemists, and engineers driven by curiosity to understand the world at the limit of a single molecule.

We study materials using nanoscale microscopy. We have the goal to inspire materials design through the following aims:

1) Approach medical & industrial material problems with a molecular, quantitative perspective using single molecule spectroscopy. Single molecule spectroscopy accesses heterogeneity hidden in traditional ensemble measurements.

2) Advance the single molecule materials field towards more complex, realistic conditions. We have a long-term vision of connecting the molecular results to the macroscale material performance.

3) Develop new microscopies that achieve a full physicochemical picture of molecular behavior. This includes how molecules adsorb, diffuse, and fold over space, time, and temperature.

Please check out our website for more details!

Image by National Cancer Institute
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Research & Discoveries

The Kisley Lab images molecules interacting with bio/soft/metal materials using microscopy.
We track how molecules stick, move, react, or change conformation over space, time, and temperature.

Image by Josie Weiss

Protein Dynamics in the Extracellular Matrix

How do proteins behave outside the cell?


Diffusion and Adsorption of Analytes in Separation Materials

Designing the most challenging separations from the bottom-up

Image by Tengyart

Imaging Corrosion, One Redox Reaction at a Time

Detecting & understanding rust right when it starts


New High-Resolution Microscopy Methods

Reaching new scales even with noisy or low signal data

Learn more about our research:

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Notable News


Congratulations - JPCB publication


Congratulations to Surajit, Stephanie, Ben, and Albert on their article "Spatially Resolving Size Effects on Diffusivity in Nanoporous Extracellular Matrix-like Materials with Fluorescence Correlation Spectroscopy Super-Resolution Optical Fluctuation Imaging" in The Journal of Physical Chemistry B. Check it out here:

Aman's 1st place poster


Aman Kapoor was awarded the 1st place presentation award in the physical sciences at CWRU's SOURCE Intersections conference. Way to represent the lab!

Lydia gives Kavli Emerging Leader in Chemistry Lecture at Spring ACS


Lydia was honored to present a keynote Kavli lecture at the ACS National Meeting in Indianapolis. She shared how we study materials with single-molecule microscopy to impact the many subfields that intersect with physical chemistry at the "crossroads of chemistry."

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Contact Us

Rockefeller Bldg.
2076 Adelbert Rd.
Cleveland, OH 44106-7079


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